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Symbol Name ID |
Ticam1
TIR domain containing adaptor molecule 1 MGI:2147032 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Mouse Phenotypes | immune system phenotype |
myocarditis |
decreased macrophage apoptosis |
decreased splenocyte proliferation |
impaired macrophage phagocytosis |
decreased susceptibility to induced colitis |
increased neutrophil cell number |
increased plasmacytoid dendritic cell number |
decreased CD8-positive, alpha-beta T cell number |
increased macrophage cell number |
increased Ly6C high monocyte number |
decreased Ly6C low monocyte number |
impaired neutrophil recruitment |
abnormal B cell physiology |
abnormal B cell activation |
decreased IgG2a level |
decreased IgG level |
abnormal NK cell physiology |
impaired natural killer cell mediated cytotoxicity |
abnormal NK T cell physiology |
abnormal macrophage physiology |
decreased macrophage cytokine production |
decreased macrophage nitric oxide production |
abnormal microglial cell physiology |
decreased circulating interferon-gamma level |
decreased circulating interleukin-12b level |
decreased circulating interleukin-6 level |
abnormal circulating tumor necrosis factor level |
decreased circulating tumor necrosis factor level |
abnormal cytokine level |
abnormal chemokine level |
abnormal interleukin level |
abnormal dendritic cell physiology |
decreased susceptibility to type I hypersensitivity reaction |
abnormal cytokine secretion |
decreased interferon-beta secretion |
increased interferon-beta secretion |
decreased interleukin-12b secretion |
decreased interleukin-6 secretion |
decreased tumor necrosis factor secretion |
decreased susceptibility to endotoxin shock |
abnormal response to infection |
decreased susceptibility to bacterial infection |
increased susceptibility to bacterial infection |
increased susceptibility to Coronaviridae infection induced morbidity/mortality |
increased susceptibility to Picornaviridae infection induced morbidity/mortality |
increased susceptibility to Herpesvirales infection |
abnormal susceptibility to Poxviridae infection |
increased susceptibility to Coronaviridae infection |
decreased susceptibility to Orthomyxoviridae infection |
increased susceptibility to Picornaviridae infection |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticam1Lps2/Ticam1Lps2 | * | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticam1M2Btlr/Ticam1M2Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticam1M3Btlr/Ticam1M3Btlr | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticam1tm1Aki/Ticam1tm1Aki | * | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticam1tm1Tsse/Ticam1tm1Tsse | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticam1M2Btlr/Ticam1+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ticam1M3Btlr/Ticam1+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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